Reaction Paper On Type 2 Diabetes - 968 Words

Discussion Epidemiological studies have proven that BGF is an independent high mortality risk factor for diabetic patients due to vascular complications 26, 27. Nevertheless, the molecular mechanism underlying this process is unclear. In parallel, miRs are known as key mediators in multiple physiological and pathological conditions, but their involvement in the detrimental effects of BGF is unknown. The objective of the present study was double: first, we aimed to confirm the detrimental effects of BGF on vascular endothelial complications in type 2 diabetes; secondly, we intended to scrutinize the possible involvement of miR-34 family members in this process. We showed that BGF exacerbated the detrimental effects associated with type 2†¦show more content†¦Significantly increased ET-1 level was found in all diabetes model rats. Furthermore, ET-1 level was highest in the FHG group. Combining the previous researches and our results, BGF might increase the risk of cardiovascular complica tions in diabetic patients. Oxidative stress is associated with postprandial hyperglycaemia via destroying the natural antioxidant defense of systems and organs 7. SOD activity indirectly reflects the antioxidant capacity, and the level of MDA indirectly reflects the degree of cells damage by oxygen free radical 36. Largely diminished SOD activity and increased MDA content were measured in BGF model compared with other diabetes model according to a previous study 37. Oxidative stress is produced in the skin of diabetic mice with BGF, which accelerates the skin damage 37. Consistently, the level of SOD was lowest while MDA level was highest in the FHG model rats, which might suggest the most severe oxidative stress injury caused by BGF. Furthermore, NO plays important roles in many processes, including immune, cardiovascular and nervous systems 38, 39. Recent evidence suggests that NO can cause net hemodynamic changes through interacting with other vasodilation mediators, such as adenosine and prostacyclin 40.Sh ow MoreRelatedDiabetes Mellitus : Type 1 Diabetes1017 Words   |  5 PagesBushaw Diabetes Mellitus: Type 1 Diabetes Research Paper 11/16/2014 Diabetes Mellitus also known as—Juvenile Onset Diabetes, Type 1 Diabetes, and Insulin Dependent Diabetes. It is a chronic autoimmune disease described by high blood glucose levels due to insulin levels being inadequate to maintain normal glucose levels. This research paper will discuss the symptoms and signs, etiology, who it triggers, how it happen, and treatment for Type 1 Diabetes. Symptoms and signs of Type 1 Diabetes are hyperglycemiaRead MoreGlucose: The Most Important Monosaccharide in the Body1038 Words   |  4 Pagesserves such important functions, understanding the biochemistry and clinical applications of malfunction of glucose metabolism are important. 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